بررسی تاثیر عسل بر بهبودی زخم ایجاد شده در معده موش آزمایشگاهی

Background and purpose: Üp to now, many researches in the fields of drugs effects and surgical procedures in treatment of all sorts of ulcers have been done. Ïn this research, therapeutic properties of honey on peptic ulcer have been studied. Honey is one of the best food stuff enriched in carbohydrate and protein. Ït has antibacterial property. Studies have shown that with increase in term of using honey for ulcer, rate of healing increases. Materials and methods : Ïn this study, 80 mice of 30 to 50 grams were selected, at first they were kept hungery for 48hr then ulcer was produced through orally given indometacin 30 mg/kg. Then mice were divided in two groups. To the control group water and food and to the case group water, food and honey in 5% dilution were fed. The mice were killed after 14 and 21 days of the regimen. Âfter dessection, macroscopic apperance of the ulcer was observed by a pathologist without Knowing the food regimen of the mice. Then slide prepration of the pathologic sample was done and studied. Results : Üp to the end of 21st day, 26 mice were died, which were excluded from the study. Microscopic study showed that from 30 mice under honey regimen, 19 did not produce ulcer, but 11 produced ulcer, and from 24 mice without honey regimens, 8 did not produce ulcer, and 16 produced ulcer, Â significant difference of ulcer healing in the mice with honey regimen was present as compared to the mice without honey regimens (P<0.01). Çonclusion : Determination of degree correlation between consumption of honey and peptic ulcer showed that, honey is effective on the ulcer produced in mice.